Cytokine regulation is complex and involves multiple levels of control:
Gene Expression: The transcription of cytokine genes is tightly regulated by transcription factors and signaling pathways. Post-transcriptional Regulation: mRNA stability and translation efficiency can affect cytokine production. Secretion: Cytokines are often produced as inactive precursors that require cleavage for activation. Receptor Expression: The availability of cytokine receptors on target cells can modulate sensitivity to cytokines. Feedback Mechanisms: Negative feedback loops involving other cytokines or signaling molecules can limit cytokine activity.
