Can lifestyle modifications have long-term histological effects?

Yes, lifestyle modifications such as diet, exercise, and smoking cessation can have significant long-term histological effects. Regular physical activity can enhance muscle fiber composition, increase capillary density, and improve mitochondrial function in skeletal muscle. A diet rich in antioxidants can reduce oxidative stress and inflammation, potentially preventing chronic diseases like atherosclerosis. Smoking cessation can lead to gradual improvement in lung tissue, with decreased inflammation and partial reversal of some structural damage over time.