Are there any permanent histological changes after long-term corticosteroid use?
Long-term use of corticosteroids can lead to permanent histological changes in certain tissues. For example:
- Skin: Prolonged use may result in permanent thinning and atrophy. - Bone: Chronic corticosteroid use can cause osteoporosis, characterized by reduced bone density and changes in trabecular architecture. - Muscle: Long-term use can lead to muscle atrophy, which may not fully reverse even after discontinuation.
