Caldesmon can be studied using various histological techniques: 1. Immunohistochemistry (IHC): Specific antibodies against caldesmon are used to stain tissue sections, allowing visualization of its distribution and expression levels. 2. Western Blotting: This technique is used to detect and quantify caldesmon protein levels in tissue extracts. 3. Immunofluorescence: Fluorescently labeled antibodies can be used to study the localization and dynamics of caldesmon in live or fixed cells.