How do tissues respond histologically after stopping corticosteroids?
Upon discontinuation of corticosteroids, tissues generally undergo a process of recovery and regeneration. The degree and timeline of recovery can vary:
- Liver: Hepatocytes may return to their original size, and overall liver architecture can normalize. - Skin: The epidermis may thicken, and dermal collagen can gradually increase. - Bone: Osteoblast activity may resume, leading to increased bone formation and density.
