In the context of histology, the Nrf2 pathway is crucial for maintaining tissue integrity and function. Tissues exposed to high levels of oxidative stress, such as the liver, lungs, and kidneys, rely heavily on Nrf2-mediated responses to prevent damage. For instance, in liver histology, activation of the Nrf2 pathway can mitigate liver fibrosis and hepatocellular damage by reducing oxidative stress.
