FAP has gained considerable interest in oncology due to its selective expression in cancer-associated fibroblasts (CAFs) and its role in promoting tumor progression. FAP-positive fibroblasts create a favorable microenvironment for tumor cells by remodeling the ECM, enhancing angiogenesis, and suppressing anti-tumor immune responses. Consequently, FAP is considered a potential target for cancer therapy, and several FAP-targeted drugs and imaging agents are under investigation.