The deregulation of CDK4 activity is a hallmark of many cancers. Overexpression or amplification of CDK4 gene can lead to unchecked cell division, contributing to tumorigenesis. For example, CDK4 is frequently amplified in melanoma and certain types of sarcomas. Understanding CDK4's role can help in developing targeted therapies, such as CDK4/6 inhibitors, which are used in treating various cancers.
