Several factors can contribute to cancer misdiagnosis in histology:
Sample Quality: Poor-quality or insufficient biopsy samples can lead to inaccurate diagnoses. Technical Errors: Mistakes during the sample processing, staining, or sectioning stages can obscure critical features needed for accurate diagnosis. Pathologist Expertise: The pathologist's experience and expertise play a significant role. Misinterpretation of cellular abnormalities can lead to incorrect conclusions. Subtlety of Disease: Early-stage cancers or cancers with subtle histological features can be challenging to identify, increasing the risk of misdiagnosis. Similar-Looking Conditions: Benign conditions or non-cancerous diseases may mimic the histological appearance of cancer, leading to false positives.
