The liver is one of the primary organs affected by MCADD, as it is a central hub for fatty acid metabolism. Histological examination of liver biopsies from individuals with MCADD often reveals microvesicular steatosis. The heart and skeletal muscles are also affected due to their reliance on fatty acids for energy, especially during increased energy demands. In severe cases, the brain may be impacted, leading to encephalopathy, which can be observed as spongiform changes in brain tissue.
