What Techniques Are Used to Study These Correlations?
Several techniques are employed to study genotype-phenotype correlations in histology:
Immunohistochemistry (IHC): This technique uses antibodies to detect specific proteins in tissue sections, helping to correlate protein expression with genetic mutations. Fluorescence in situ hybridization (FISH): FISH helps identify genetic abnormalities at the chromosomal level by using fluorescent probes, providing insights into how these abnormalities affect tissue structure. Next-generation sequencing (NGS): NGS allows for comprehensive analysis of genetic variations, which can be correlated with histological findings to understand their impact on tissue morphology.
