What Techniques are Used in Histological Studies for Pharmacokinetics?
Several histological techniques are employed in pharmacokinetic studies, including:
1. Immunohistochemistry (IHC): This technique uses antibodies to detect specific proteins within tissue sections, allowing for the visualization of drug targets or biomarkers. 2. In Situ Hybridization (ISH): ISH is used to detect specific nucleic acid sequences within tissues, providing insights into gene expression changes induced by drugs. 3. Autoradiography: This technique uses radioactive compounds to trace the distribution of drugs within tissues, offering a visual representation of drug localization. 4. Fluorescence Microscopy: This method employs fluorescent labels to track the distribution and accumulation of drugs within tissues and cells.
