Keratinocytes are the predominant cell type in the epidermis and play a significant role in the skin barrier function. As they differentiate and move from the basal layer to the stratum corneum, they undergo a series of changes, including the synthesis of keratin proteins and the formation of a cornified envelope. This process is tightly regulated and involves numerous signaling pathways. The final stage of keratinocyte differentiation results in the formation of corneocytes, which are essential components of the skin barrier.
