How Does the Skin Barrier Protect Against Microbial Invasion?
The skin barrier is also a critical component of the innate immune system. The physical barrier provided by the stratum corneum prevents the entry of pathogens. Additionally, the skin secretes antimicrobial peptides and other immune molecules that offer further protection. Resident immune cells, such as Langerhans cells in the epidermis, are also part of the defense mechanism, identifying and responding to microbial threats.
