What roles do different organs play in iron homeostasis?
Several organs contribute to iron homeostasis in distinct ways:
Liver: The liver produces hepcidin, which inhibits iron export by binding to ferroportin, leading to its degradation. The liver also stores excess iron in the form of ferritin and hemosiderin. Spleen: The spleen recycles iron from senescent red blood cells, releasing it back into the circulation for reuse. Bone Marrow: The bone marrow utilizes iron for the synthesis of hemoglobin in developing red blood cells. Intestine: The duodenum absorbs dietary iron and regulates its entry into the bloodstream.
