The tumor microenvironment (TME) is a complex network of cells, signaling molecules, and extracellular matrix surrounding the tumor. It plays a critical role in cancer progression and response to immunotherapy. Histological analysis of the TME can reveal the presence of immune suppressive cells like regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), which can inhibit the efficacy of immunotherapy. Understanding the TME helps in the development of combination therapies that can modulate the TME to enhance the immune response.
