How does histology aid in the diagnosis of immune deficiencies?
Immune deficiencies, whether congenital or acquired, can present specific histological features:
- Lymphoid Tissue Hypoplasia: Underdeveloped lymphoid tissues, such as in severe combined immunodeficiency (SCID). - Reduced Germinal Centers: Indicates impaired antibody production, as seen in common variable immunodeficiency (CVID). - Opportunistic Infections: Presence of infections by organisms that usually do not cause disease in immunocompetent individuals, often highlighted by histological examination.
