What Role Does CTCF Play in Development and Disease?
CTCF is essential for proper embryonic development, as it regulates the expression of genes critical for cell differentiation and growth. In addition to its role in normal development, CTCF dysfunction has been implicated in various diseases. For example, mutations or aberrant expression of CTCF have been linked to cancer, where they can lead to uncontrolled cell proliferation and tumorigenesis. Furthermore, CTCF has been associated with neurological disorders, highlighting its importance in maintaining genomic stability and proper gene function.
