In histology, CTCF can be studied using various techniques such as immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). These methods allow researchers to visualize the localization and expression levels of CTCF in different tissues and cellular contexts. Additionally, chromatin immunoprecipitation (ChIP) combined with sequencing (ChIP-seq) is frequently used to map CTCF binding sites across the genome and understand its role in chromatin architecture and gene regulation.