Dysfunction in SERCA pumps is implicated in various diseases. For instance, in heart failure, impaired SERCA function leads to inadequate calcium reuptake, resulting in reduced cardiac output. Mutations in [SERCA genes]() are also linked to conditions such as Brody disease, a rare muscle disorder characterized by muscle stiffness and cramps. Additionally, altered SERCA activity is associated with certain types of cancer, where it affects cell proliferation and apoptosis.
