Bone resorption is regulated by various factors including: - Hormones: Parathyroid hormone (PTH) increases bone resorption, while calcitonin inhibits it. - Cytokines: RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand) and OPG (Osteoprotegerin) play crucial roles. RANKL promotes osteoclast differentiation and activity, whereas OPG acts as a decoy receptor to inhibit RANKL. - Mechanical Stress: Physical activity stimulates bone formation and reduces resorption.
