The immune synapse is organized into distinct regions known as supramolecular activation clusters (SMACs). These regions include the central SMAC (cSMAC), the peripheral SMAC (pSMAC), and the distal SMAC (dSMAC). The cSMAC contains the T cell receptor (TCR) and associated signaling molecules, the pSMAC is enriched with adhesion molecules like LFA-1, and the dSMAC consists of actin cytoskeleton components.
