The formation of an immune synapse begins with the recognition of an antigen presented by the APC. Upon antigen recognition, the TCRs cluster in the cSMAC and initiate signaling cascades. This is followed by the recruitment of adhesion molecules to the pSMAC, which stabilizes the interaction. Finally, actin reorganization occurs at the dSMAC, facilitating the polarization of the T cell and the directed secretion of effector molecules.
