TNF-α is a key mediator of inflammation. It acts by binding to its receptors, TNFR1 and TNFR2, on the surface of various cell types, leading to the activation of signaling pathways that result in the production of other pro-inflammatory cytokines, chemokines, and adhesion molecules. This cascade of events enhances the inflammatory response and recruits more immune cells to the site of infection or injury.
