Stellate cells are involved in the pathogenesis of several diseases:
Liver Fibrosis: Activated hepatic stellate cells are the primary source of collagen and other extracellular matrix components in liver fibrosis, which can progress to cirrhosis. Pancreatic Cancer: Pancreatic stellate cells interact with cancer cells, promoting tumor growth, metastasis, and resistance to therapy. Neurodegenerative Diseases: Dysregulated astrocyte function is associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
