Keratohyalin granules are essential for the process of keratinization. They contain large amounts of profilaggrin, which is cleaved into filaggrin in the stratum corneum. Filaggrin plays a vital role in binding keratin fibers together, leading to the formation of a strong, protective layer. These granules also contain other proteins and enzymes that contribute to the cross-linking of keratin fibers and the formation of a hydrophobic barrier.