What is the Role of Keratinocyte Apoptosis in Skin Disorders?
Abnormal keratinocyte apoptosis is implicated in a variety of skin disorders. Excessive apoptosis can lead to conditions like atopic dermatitis and psoriasis, where the turnover of skin cells is disrupted. Conversely, insufficient apoptosis can contribute to skin cancers, as damaged cells evade death and undergo uncontrolled proliferation. Understanding the balance of apoptosis in keratinocytes is therefore essential for developing therapeutic strategies for these conditions.
