What is the Clinical Significance of KRAS in Cancer?
KRAS mutations are prognostic and predictive biomarkers. In colorectal cancer, the presence of a KRAS mutation predicts poor response to anti-EGFR therapy. Therefore, testing for KRAS mutations is essential for guiding treatment decisions. In pancreatic cancer, KRAS mutations are almost ubiquitous, making it a critical target for drug development.
