The formation of the organic matrix involves the secretion of various proteins by cells such as osteoblasts in bone and chondrocytes in cartilage. These cells produce and extrude collagen and other matrix components into the extracellular space, where they assemble into a structured network. The process is tightly regulated by signaling pathways and the activity of enzymes such as matrix metalloproteinases (MMPs), which remodel the matrix as necessary.
