FGFR3 plays a pivotal role in the regulation of bone growth. In the histological context, it is involved in the endochondral ossification process, where cartilage is replaced by bone. FGFR3 signaling limits the proliferation of chondrocytes and promotes their differentiation. Mutations in this gene can lead to growth disorders such as achondroplasia and hypochondroplasia, characterized by shortened bones and dwarfism.
