What are Some Disorders Associated with Megakaryocytes?
Several disorders can affect megakaryocytes, leading to abnormal platelet production. Thrombocytopenia is a condition characterized by a low platelet count, which can result from impaired megakaryocyte function. Essential thrombocythemia is a disorder where there is an overproduction of platelets due to abnormal megakaryocyte proliferation. Additionally, myelofibrosis is a condition where fibrous tissue replaces bone marrow, affecting megakaryocyte function and leading to various hematological abnormalities.
