What is the Relevance of Histological Findings in Different INSS Stages?
Histological findings vary at different stages of neuroblastoma:
Stage 1 and 2: Tumors are generally more localized with less histological complexity. The cellular architecture is often better preserved. Stage 3: Tumors show more invasive characteristics, crossing midline structures, and may exhibit increased mitotic activity and necrosis. Stage 4: Distant metastases are common, and histological examination may reveal tumor cells in multiple organs, characterized by a higher degree of anaplasia. Stage 4S: Despite dissemination, the histology may resemble lower stages, often with less aggressive features, which correlates with a better prognosis in infants.
