The INSS stage significantly influences treatment strategies. For example:
Stage 1: Often treated with surgery alone. Stage 2: May require surgery followed by chemotherapy or radiation if the resection is incomplete. Stage 3: Typically requires multimodal treatment including surgery, chemotherapy, and possibly radiation therapy. Stage 4: Involves aggressive treatment with high-dose chemotherapy, radiation, and sometimes stem cell transplant. Stage 4S: Often managed with observation or minimal intervention due to the potential for spontaneous regression.
