A histopathological examination of a biopsy or resected tumor sample is essential for diagnosing neuroblastoma. The histological features include small, round, blue cells with a high nuclear-to-cytoplasmic ratio, characteristic Homer-Wright rosettes, and often dense fibrillary material. Immunohistochemical staining for markers such as neuron-specific enolase (NSE), chromogranin A, and synaptophysin can aid in the diagnosis.
