What is the Mechanism of Action of DNA Glycosylase?
DNA glycosylase identifies and excises damaged bases by cleaving the N-glycosidic bond between the base and the sugar-phosphate backbone of the DNA. This action results in the formation of an apurinic/apyrimidinic (AP) site. The AP site is then processed by AP endonuclease, which cuts the DNA backbone, allowing further repair mechanisms to restore the DNA sequence.
