What Are the Clinical Implications of DNA Glycosylase Activity?
Aberrant DNA glycosylase activity is implicated in various diseases. Reduced activity can lead to accumulation of DNA damage, contributing to cancer development. Conversely, overactive DNA glycosylases might interfere with normal cellular processes, leading to genomic instability. Therefore, DNA glycosylase activity is a potential target for therapeutic interventions in diseases characterized by DNA damage and repair deficiencies.
