What is the Histological Basis of Muscular Dystrophies?
Muscular dystrophies are a group of genetic disorders characterized by progressive muscle weakness and degeneration. Histologically, they typically show:
- Fiber Size Variation: Due to cycles of degeneration and regeneration. - Increased Connective Tissue: Fibrosis and fatty infiltration replacing muscle tissue over time. - Necrotic and Regenerating Fibers: Indicative of ongoing muscle damage and repair.
Duchenne Muscular Dystrophy (DMD), one of the most severe forms, shows extensive muscle fiber necrosis, marked regeneration, and significant fibrosis and adipose tissue replacement.
