What Histological Features are Observed in Metabolic Myopathies?
Metabolic myopathies result from defects in biochemical pathways within muscle cells. Histological features include:
- Glycogen and Lipid Accumulation: Seen in conditions like glycogen storage diseases and lipid storage myopathies. - Ragged Red Fibers: Mitochondrial myopathies show muscle fibers with abnormal mitochondrial accumulations, often highlighted by special stains like Gomori trichrome. - Crystalline and Amorphous Inclusions: Indicating abnormal storage products within muscle fibers.
