Histologically, the germinal centers where CSR occurs can be identified as densely packed regions within lymphoid follicles. These areas contain proliferating B cells, follicular dendritic cells, and helper T cells. The presence of tingible body macrophages, which engulf apoptotic B cells, is also a characteristic feature. Immunohistochemical staining can identify specific markers such as AID and CD40, providing further evidence of ongoing CSR.
