TrkB functions as a high-affinity receptor for BDNF and NT-4, facilitating neuronal survival, growth, and differentiation. It is involved in synaptic plasticity, which is essential for learning and memory. Upon binding with its ligands, TrkB undergoes dimerization and autophosphorylation, activating downstream signaling pathways like the PI3K/Akt pathway and the MAPK/ERK pathway.
