TrkB - Histology

What is TrkB?

TrkB, short for Tropomyosin receptor kinase B, is a protein that in humans is encoded by the NTRK2 gene. It acts as a receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). TrkB plays a crucial role in the development and function of the nervous system by mediating the effects of these neurotrophins.

Where is TrkB Located?

TrkB is predominantly found in the central nervous system (CNS), including the brain and spinal cord. Its presence is also noted in peripheral tissues, albeit at lower levels. Within the CNS, TrkB is highly expressed in regions such as the hippocampus, cortex, and basal ganglia.

What is the Function of TrkB?

TrkB functions as a high-affinity receptor for BDNF and NT-4, facilitating neuronal survival, growth, and differentiation. It is involved in synaptic plasticity, which is essential for learning and memory. Upon binding with its ligands, TrkB undergoes dimerization and autophosphorylation, activating downstream signaling pathways like the PI3K/Akt pathway and the MAPK/ERK pathway.

How is TrkB Studied in Histology?

In histological studies, TrkB can be localized and quantified using techniques such as immunohistochemistry (IHC) and in situ hybridization. These methods employ specific antibodies or nucleic acid probes to detect TrkB in tissue sections. The resulting images can reveal TrkB's distribution across different tissues and cell types, providing insights into its functional roles.

What are the Clinical Implications of TrkB?

Alterations in TrkB signaling have been linked to various neurological disorders, including Alzheimer's disease, depression, and epilepsy. In Alzheimer's, reduced TrkB expression is associated with neurodegeneration, while in depression, impaired BDNF-TrkB signaling contributes to mood dysregulation. Targeting TrkB pathways is therefore a promising therapeutic approach for these conditions.

What are the Future Directions in TrkB Research?

Future research on TrkB aims to elucidate its precise roles in various physiological and pathological contexts. Advances in gene editing technologies, such as CRISPR/Cas9, will enable more detailed studies of TrkB function at the genetic level. Additionally, the development of specific TrkB agonists and antagonists holds potential for novel therapeutic interventions.

Relevant Publications

Huanglian Wendan Decoction Improves Insomnia in Rats by Regulating BDNF/TrkB Signaling Pathway Through Gut Microbiota-Mediated SCFAs and Affecting Microglia Polarization.

Issue Release: 2024

Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents.

Issue Release: 2024

Retrograde adenosine/A receptor signaling facilitates excitatory synaptic transmission and seizures.

Issue Release: 2024

Investigating 7,8-Dihydroxyflavone to combat maternal immune activation effects on offspring gene expression and behaviour.

Issue Release: 2024

Intranasal delivery of liposome encapsulated flavonoids ameliorates l-DOPA induced dyskinesia in hemiparkinsonian mice.

Issue Release: 2024

Pyrazolo[1,5-]pyrimidine as a Prominent Framework for Tropomyosin Receptor Kinase (Trk) Inhibitors-Synthetic Strategies and SAR Insights.

Issue Release: 2024

The Antidepressant Action of Fluoxetine Involves the Inhibition of in Cortical GABAergic Neurons through a TrkB-Dependent Pathway.

Issue Release: 2024

Role of Brain Derived Neurotrophic Factor and Related Therapeutic Strategies in Central Post-Stroke Pain.

Issue Release: 2024

Neuroprotection by ADAM10 inhibition requires TrkB signaling in the Huntington\'s disease hippocampus.

Issue Release: 2024

Effect of electroacupuncture on proBDNF/mBDNF and synaptic plasticity in rats with learning and memory impairment after cerebral ischemia-reperfusion.

Issue Release: 2024

Exertional heat stroke-induced changes in gut microbiota cause cognitive impairment in mice.

Issue Release: 2024

Connecting the Emotional-Cognitive Puzzle: The Role of Tyrosine Kinase (TrkB) Receptor Isoform Imbalance in Age-Related Emotional and Cognitive impairments.

Issue Release: 2024

PLC-γ-Ca pathway regulates axonal TrkB endocytosis and is required for long-distance propagation of BDNF signaling.

Issue Release: 2024

Tao-Hong-Si-Wu-Tang Improves the Depressive-like Behaviors in Mice Experiencing Perimenopausal Depression Through Modulating Activity of the Hypothalamic-Pituitary-Adrenal-Ovary Axis and Activating the BDNF-TrkB-CREB Signaling Pathway.

Issue Release: 2024

Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice.

Issue Release: 2024

Enhancing Cognitive Functions and Neuronal Growth through NPY1R Agonist and Ketamine Co-Administration: Evidence for NPY1R-TrkB Heteroreceptor Complexes in Rats.

Issue Release: 2024

Corrigendum to \"The BDNF mimetic R-13 attenuates TBI pathogenesis using TrkB-related pathways and bioenergetics.\" [BBA: Mol. Basis. Dis. 1869 (2023) 166781].

Issue Release: 2024

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice.

Issue Release: 2024

Network Pharmacology Combined with Animal Models to Investigate the Mechanism of ChangPu YuJin Tang in the Treatment of Tourette Syndrome.

Issue Release: 2024

Vagus nerve stimulation (VNS) modulates synaptic plasticity in the infralimbic cortex via Trk-B receptor activation to reduce drug-seeking in male rats.

Issue Release: 2024

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