PDGFRα binds to its ligands, PDGF-AA, PDGF-BB, and PDGF-CC, initiating a cascade of intracellular signaling pathways. This activation leads to various cellular responses, including growth, survival, migration, and differentiation. In the context of histology, PDGFRα is particularly important for wound healing, tissue regeneration, and the maintenance of the extracellular matrix. It also plays a role in the development of fibrotic diseases due to its involvement in the proliferation of fibroblasts and the production of collagen.
