Aberrant signaling through PDGFRα has been implicated in several pathological conditions. Overexpression or mutation of PDGFRA can lead to oncogenesis and is associated with various cancers, including glioblastoma, gastrointestinal stromal tumors (GISTs), and certain types of leukemia. Additionally, abnormal PDGFRα signaling is linked to fibrotic diseases such as pulmonary fibrosis and liver cirrhosis, where it contributes to excessive tissue scarring and organ dysfunction.
