Immune suppressive cells are significant in various clinical contexts, including autoimmunity, infection, and cancer. In autoimmune diseases, an imbalance in these cells can lead to an inadequate suppression of immune responses, resulting in tissue damage. In cancer, these cells often accumulate in the tumor microenvironment and contribute to immune evasion by the tumor. Targeting immune suppressive cells or their pathways is a promising therapeutic strategy in oncology and autoimmunity.
