Neuron Specific Enolase (NSE) is an enzyme found in the cytoplasm of neurons and neuroendocrine cells. It is one of the three isoenzymes of enolase, an enzyme that plays a crucial role in the glycolytic pathway by catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate. NSE is a highly specific marker for neurons and can be used to identify both normal and neoplastic neural tissue in histological studies.
