What is the Clinical Significance of Keratohyalin Granules?
Keratohyalin granules are essential for maintaining the barrier function of the skin. Abnormalities in their formation or function can lead to various skin disorders. For example, mutations in the genes encoding proteins found in keratohyalin granules are associated with conditions such as ichthyosis vulgaris and atopic dermatitis. These disorders often result in compromised barrier function and increased skin sensitivity.
