What Happens to Keratohyalin Granules During Keratinocyte Differentiation?
As keratinocytes differentiate and move from the stratum granulosum to the stratum corneum, keratohyalin granules undergo enzymatic degradation. The proteins within the granules, such as profilaggrin, are processed into their functional forms (e.g., filaggrin), which then participate in the formation of the keratinized layer. The degradation of keratohyalin granules is a crucial step in the terminal differentiation of keratinocytes.
