What is the Role of Profilaggrin in Keratohyalin Granules?
Profilaggrin is a major component of keratohyalin granules and serves as a precursor to filaggrin. Upon enzymatic processing, profilaggrin is cleaved into filaggrin monomers, which then bind to keratin filaments, promoting their aggregation into tight bundles. This process is essential for the formation of the stratum corneum and the overall barrier function of the skin.
