What are the therapeutic implications of targeting PSEN2?
Understanding the role of PSEN2 in the pathology of Alzheimer’s disease opens avenues for potential therapeutic interventions. Targeting PSEN2 or the gamma-secretase complex to modulate its activity could help reduce amyloid-beta production. However, given the complex role of gamma-secretase in processing multiple substrates, therapies must be designed to minimize potential side effects. Research is ongoing to develop inhibitors that selectively target the pathogenic activity of PSEN2 without disrupting its normal physiological functions.
