Dysfunction of the submucosal plexus can lead to various GI disorders. For instance, abnormalities in its neuronal network can contribute to conditions such as [irritable bowel syndrome](https://en.wikipedia.org/wiki/Irritable_bowel_syndrome) (IBS) and chronic inflammatory diseases like [Crohn's disease](https://en.wikipedia.org/wiki/Crohn%27s_disease). Understanding its role can help in developing therapeutic strategies aimed at alleviating these conditions.
